The novel genes Gpr65, Toso, and Plzp, identified by the single-cell RNA-sequencing analysis of ex vivo Th17 cells, are found to promote Th17 pathogenicity and to cause EAE and chronic inflammation in the CNS of mice, while CD5 antigen-like (CD5L) attenuates Th17 cell-mediated disease (69, 70). Here, CD5L is linked to glycogen storage disease VI.