A recent study by Hideharu et al., which involved 20 patients with overt or heavy proteinuria due to DN or minimal-change nephrotic syndrome and five healthy controls, found that WT1 mRNA in urine exosomes could be used as a biomarker in the diagnosis of type 1 DN with the AUC of 0.705 (56). Here, WT1 is linked to liver dysplastic nodule.