For hBDs, the mechanism was mediated through binding to the chemokine receptor CCR2 attracting CCR2-expressing inflammatory cells such as monocytes/macrophages, DCs, and PMNs to the sites of infection while LL-37 chemotactic activity was mediated by the G protein-coupled formyl peptide receptor-like 1 (FRPL-1) (De et al., 2000; Jia et al., 2008; Lin et al., 2008; Röhrl et al., 2010). The gene discussed is CCR2; the disease is infection.