The aim of this prospective study was to investigate the following immune-parameters in a cohort of patients with a seizure disorder immediately after the epileptic seizure compared to age-matched controls: the endocrine transmitters normetanephrine, metanephrine, and the humoral pro-inflammatory DAMPs HMGB-1 and mtDNA; changes of the adaptive immune system; classical, intermediate, and non-classical subsets of monocytes as well as pro-inflammatory, anti-inflammatory, and classical subsets of granulocytes. The gene discussed is HMGB1; the disease is epilepsy.