Two previous studies conducted in Western countries reported similar findings in both children and adults; APS at disease onset was rare in children with MOG antibodies (3.8%, 1/26) compared to those with AQP4 antibodies (50%, 4/8) (13), and APS presented only as a subsequent attack (2%, 1/50) in adults with MOG antibodies (14). This evidence concerns the gene MOG and autoimmune polyendocrinopathy.