Meanwhile, we found that LMP10 (β2i) plays a critical role in DOCA-salt-induced myocardial fibrosis and high-dose Ang II-induced atrial fibrillation and retinopathy (Yan et al., 2017; Li J. et al., 2018; Wang S. et al., 2018). The gene discussed is PSMB10; the disease is Myocardial fibrosis.