Interestingly, the present study showed that LMP10 KO markedly reduced medium-dose (1,000 ng/kg/min) Ang II-induced hypertension, but suppressed Ang II-induced cardiac hypertrophic remodeling and improved abnormal cardiac function (Figures 2–4), suggesting that LMP10 KO exerts a cardioprotective effect, likely through a blood-dependent mechanism. This evidence concerns the gene PSMB10 and hypertensive disorder.