The functional roles of LMP7 in cardiac hypertrophy, atrial fibrillation, abdominal aortic aneurysm, and retinopathy have been investigated extensively (Li F. D. et al., 2019; Li J. et al., 2019; Xie et al., 2019; Wang et al., 2020). Here, PSMB8 is linked to cardiac hypertrophy.