The Aβ fragments of APP is the major component of AD amyloid plaques, and such dysregulation of APP trafficking and processing are relevant to understanding AD pathology (Caporaso et al., 1994; Thinakaran and Koo, 2008; Zhang et al., 2011; Tan and Gleeson, 2019; Yuksel and Tacal, 2019). Here, APP is linked to Alzheimer disease.