APP and Alzheimer disease: The amyloidogenic pathway involves cleavage of APP by β-secretase in early endosomes, releasing sAPPβ fragments in the endosomal lumen, and increasing susceptibility to Aβ plaques that are relevant to AD pathology (Estus et al., 1992; Golde et al., 1992; Saftig et al., 1996; Ehehalt et al., 2003; Andrew et al., 2016; Grimm et al., 2016).