To explore the explicit mechanism of SSP regulated differentiation of Tfh via BCL-6/Blimp-1 signaling pathway in the next studies, we will induce colitis animal model in the BCL-6 knock-in mice or Blimp-1 knock-out mice, separate tissue resident Tfh cells from mesenteric lymph nodes, and analyze the activation of Bcl-6/Blimp-1 signaling pathway after colitis mice were treated by Sishen Pill or Bcl-6 inhibitor or siRNA technology. The gene discussed is PRDM1; the disease is colitis.