After 7-days’ administration of SSP and 5-ASA, the numbers of CD4+CXCR5+IL-10+ (Tfh10) (Figures 3A–C) and CD4+CXCR5+Foxp3+ (Tfr) (Figures 3A,B, E5) were dramatically increased when compared with those in colitis mice without treatment. The gene discussed is TFRC; the disease is colitis.