And, targeted ablation of BAG3 in the murine heart or expression of cardiomyopathy-associated BAG3 mutants induces myofibrillar degeneration (Hishiya et al., 2010) with increased portioning of proteins to detergent insoluble fraction (revealing their aggregate prone state) without formation of protein aggregates in the context of fulminant cardiomyopathic manifestations (Fang et al., 2017). The gene discussed is BAG3; the disease is cardiomyopathy.