HSPB2 and cardiomyopathy: While the αB-crystallin/HspB2 double knockout (due to overlapping exons), has increased stress induced cardiomyopathy with ischemia-reperfusion injury (Morrison et al., 2004) and myocardial pressure overload (Kumarapeli et al., 2008), the phenotype is not seen with a functional HspB2 knockout (Ishiwata et al., 2012), reinforcing αB-crystallin’s importance.