Activation of the autophagy-lysosome pathway by intermittent fasting or targeted activation of transcription factor EB (Settembre et al., 2011) even at an advanced stage of disease pathogenesis was sufficient to restore normal function and rescue cardiomyopathy by restoring normal desmin localization (Ma X. et al., 2019; Mukai et al., 2019). Here, DES is linked to cardiomyopathy.