DES and cardiomyopathy: While initially identified in desmin-related genetic cardiomyopathies (Goldfarb and Dalakas, 2009), these features of desmin mis-localization, as well as sarcomeric disarray, are increasingly identified as features of cardiomyopathy in general (Coats et al., 2018; Tsikitis et al., 2018; Nakano et al., 2019).