HSPB2 and cardiomyopathy: In contrast, a murine model of αB-crystallin ablation (which is accompanied with unintended ablation of Hspb2; Brady et al., 2001) results primarily in skeletal myopathy which manifests with aging; and forced overexpression of αB-crystallin mutants (such as R120G) has been required to replicate human cardiomyopathy phenotype in a much more insidious and delayed fashion (Wang et al., 2001; Rajasekaran et al., 2007).