Indeed, while mutations in candidate protein quality control machinery proteins like αB-crystallin, BAG3, HspB7, Vps34, p97 appear to play mechanistic roles in inducing dilated cardiomyopathy in genetic myofibrillar myopathies (Vicart et al., 1998; Bova et al., 1999; Fang et al., 2017; Judge et al., 2017; Kimura et al., 2017; Dominguez et al., 2018; Brody et al., 2019); variants in many of these, such as BAG3 and KLHL3 are also associated with cardiomyopathy in population-based genomic analyses (Aragam et al., 2018; Myers et al., 2018; Shah et al., 2020). This evidence concerns the gene BAG3 and dilated cardiomyopathy.