Other components of the aggresome have been uncovered in studies with laser microdissection of intracytoplasmic inclusions identified in muscle biopsies from patients with reducing body myopathy (RBM) which led to the identification of mutations in Xq26.3-encoded four and a half LIM domain 1 (FHL1) protein as a cause for cardiomyopathy (Schessl et al., 2008). The gene discussed is FHL1; the disease is cardiomyopathy.