INS and early-onset autosomal dominant Alzheimer disease: As shown in Figure 4A, for the murine datasets, metabolic, AMPK, fatty acid, PPAR signaling, insulin signaling, biosynthesis of antibiotics, biosynthesis of unsaturated fatty acids, glucagon signaling, insulin resistance pathways were enriched; for the yellow co-expression module genes, Alzheimer’s disease, MAPK signaling, oxidative phosphorylation, ABC transporters cardiac muscle contraction signaling pathways were enriched.