CD163 and hemarthrosis: In a study conducted on murine models of hemarthrosis, an iron-induced chemical damage was demonstrated, also emphasizing the pathogenic role of iron-derived metabolites [Ferroportin (an iron cell exporter); Hepcidin (regulator of FPN); Hemoglobin scavenger receptor (CD163); Heme carrier protein 1 (heme cell importer); Feline leukemia virus subgroup C (heme cell exporter)] (Nieuwenhuizen et al., 2013).