PRKN and Parkinson disease: The relationship between PD and mitochondria is further advocated by the fact that people with mutation in genes which are known to control mitochondrial degradation, like PINK1 and Parkin (Narendra et al., 2008; Geisler et al., 2010; Matsuda et al., 2010; Vives-Bauza et al., 2010; Bayne and Trempe, 2019; Biswas et al., 2020), develop a juvenile autosomal recessive form of PD (Kitada et al., 1998; Valente et al., 2004).