The hypertrophic cardiomyopathy-associated mutation F87L in the central region of cTnT enhances calcium sensitivity but attenuates LDA (Reda and Chandra, 2018) and the RCM-associated mutation hcTnIR145W does not affect LDA although it strongly increases calcium sensitivity (Dvornikov et al., 2016). Here, TNNT2 is linked to hypertrophic cardiomyopathy.