KLF6 and neoplasm: Moreover, a previous study identified the KLF6 gene as a tumor suppressor gene; for example, KLF6 inhibited the proliferation and promoted the apoptosis of clear cell renal cell carcinoma (ccRCC) cells as a target gene of both miR-543 and miR-181a (Gao et al., 2017; Lei et al., 2018; Yang et al., 2018).