Combining these findings with the prediction results for the GSE58438 GEO dataset, we found that miR-181d targeted not only KLF6 but also four other genes with increased expression in AKI: cysteine rich angiogenic inducer 61 (CYR61), CNKSR family member 3 (CNKSR3), sprouty RTK signaling antagonist 4 (SPRY4), and a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMST1). This evidence concerns the gene SPRY4 and acute kidney injury.