Previous research by our group shows that CYR61 not only has protective effects on RTECs in the early stage of I/R-AKI, but also attenuates P53/P21/Rb senescence signaling pathway to inhibit fibroblasts proliferation after renal IRI (Liu et al., 2019), though miR-181d-related CYR61 have not yet explored. Here, CCN1 is linked to acute kidney injury.