Icariin, a major bioactive component extracted from plants of the Epimedium genus (Liu et al., 2006), has been shown to ameliorate insulin resistance in skeletal muscle cells (Han et al., 2015; Li et al., 2018; Liu et al., 2019) and restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mild stress (Pan et al., 2013). Here, INS is linked to Insulin resistance.