Calcium signaling pathway; MAPK signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; cardiac muscle contraction; adrenergic signaling in cardiomyocytes; vascular smooth muscle contraction; circadian entrainment; type II diabetes mellitus; hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); dilated cardiomyopathy. The gene discussed is PRKG1; the disease is dilated cardiomyopathy.