INS and type 2 diabetes mellitus: Calcium signaling pathway; MAPK signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; cardiac muscle contraction; adrenergic signaling in cardiomyocytes; vascular smooth muscle contraction; circadian entrainment; Insulin secretion; type II diabetes mellitus; hypertrophic cardiomyopathy (HCM); arrhythmogenic right ventricular cardiomyopathy (ARVC); dilated cardiomyopathy