REN and early-onset autosomal dominant Alzheimer disease: Calcium signaling pathway; renin-angiotensin system; Alzheimer's disease; adrenergic signaling in cardiomyocytes; Thyroid hormone signaling pathway; Alzheimer's disease; hypertrophic cardiomyopathy (HCM); arrhythmogenic right ventricular cardiomyopathy (ARVC); dilated cardiomyopathy