As it most-often occurs in patients with reduced repolarization reserve (see above), the use of various transgenic LQTS rabbit models (Brunner et al., 2008; Major et al., 2016) with increased sensitivities to potassium channel blocking effects and different degrees of impairment in their cardiac repolarization reserve, is expected to provide more reliable, and more thorough detection of (multi-channel-based) drug-induced ventricular arrhythmias. This evidence concerns the gene KCNA3 and familial long QT syndrome.