One frequently used drug-induced model is the methoxamine-sensitized rabbit model: anesthetized rabbits are sensitized with the selective α-adrenoceptor-agonist methoxamine, which makes them particularly prone to develop drug-induced ventricular tachycardia when exposed to HERG/IKr-blocking drugs (Carlsson, 2008; Carlsson et al., 2009). The gene discussed is KCNH2; the disease is ventricular tachycardia.