All available transgenic LQTS rabbit models have been engineered by beta-myosin heavy chain promoter-driven cardio-selective over-expression of mutated human genes encoding for voltage-gated K+ channels such as KCNQ1/KvLQT1 (KvLQT1-Y315S, LQT1), KCNH2/HERG (HERG-G628S, LQT2), or KCNE1/minK (KCNE1-G52R) (Brunner et al., 2008; Major et al., 2016). The gene discussed is KCNQ1; the disease is familial long QT syndrome.