Compared with the vehicle control group, the protein levels of p-p38, p-JNK, p-IKK, p-TAK1, and AP-1 were significantly increased in the COPD model group while the expression of p-IKK in the CPE group was not significantly decreased compared to the model group (p >0.05). The gene discussed is FOS; the disease is chronic obstructive pulmonary disease.