NFKB1 and Familial prostate cancer: Upon exposure to 20-HETE, the prostate cancer cell line PC-3 internalized GPR75, resulted in the phosphorylation of signaling molecules EGFR, NF-κB, and AKT, and altered cellular localization of AKT, NF-κB, and PKCα, all of which were reversed with the addition of GPR75 antagonist (Cárdenas et al., 2019).