CYP2J2 increased lung metastasis in mice xenograft models, independent of primary tumor size, (Jiang et al., 2007) while chemically inhibiting CYP2J2 activity, using compounds structurally related to terfenadine, significantly reduced the tumor cells' ability for adhesion and invasion (Chen et al., 2009). The gene discussed is CYP2J2; the disease is neoplasm.