P2RX7 and malignant colon neoplasm: While nfP2X7 was identified in the human HT-29 and Colo-205 colon cancer cell lines (Barden et al., 2009), other reports have shown P2X7 expression in human HCT8, Caco-2, Colo-205, and murine MCA38 colon cancer cell lines and the latter cell line was found to possess functional P2X7 macropore (Coutinho-Silva et al., 2005; Kunzli et al., 2011; Bian et al., 2013).