P2RX7 and neoplasm: Despite this attenuation of pore function, it is clear from a number of studies that the P2X7 expressed in these cancer cells retains significant signaling functionality and the ability to drive the formation, survival and metastatic potential of tumor cells as previously reported (Jelassi et al., 2011; Adinolfi et al., 2012a; Amoroso et al., 2015; De Marchi et al., 2019; Gilbert et al., 2019).