P2X7 is also overexpressed in a number of cancer types, potentially driving tumor development and survival (Adinolfi et al., 2002; Adinolfi et al., 2009; Adinolfi et al., 2012; Barden et al., 2014; Amoroso et al., 2015; Barden et al., 2016; Gilbert et al., 2019). This evidence concerns the gene P2RX7 and neoplasm.