Indeed, overexpression of full length P2X7 was shown to promote tumor growth (Jelassi et al., 2011; Adinolfi et al., 2012a), while P2X7 blockade was shown to inhibit neoplastic growth in several experimental models (Adinolfi et al., 2012a; Adinolfi et al., 2015a; Amoroso et al., 2015; Amoroso et al., 2016; Giannuzzo et al., 2016; De Marchi et al., 2019; Zhang et al., 2019a). The gene discussed is P2RX7; the disease is neoplasm.