The beneficial effects of irisin on metabolic disorders are associated with not only the driving of the browning of white adipose tissue, increasing the energy expenditure, but also suppressing inflammatory response and oxidative stress (Polyzos et al., 2014; Dulian et al., 2015; Lu et al., 2015; Zhu et al., 2015). The gene discussed is FNDC5; the disease is metabolic disease.