PTGS2 and melanoma: Timo AIII suppressed the migration capability of murine melanoma cell B16-F10 and human melanoma cell WM-115, which were induced or not induced by COX-2 stimulator 12-O-tetradecanoylphorbal-13-acetate (TPA), and it was closely associated with its concentration-dependent inhibitory effect on endogenous COX-2 expression and PGE2 production (Kim et al., 2016).