BCL2 and familial pancreatic carcinoma: In pancreatic cancer, Kim et al. demonstrated that Timo AIII increased the number of apoptotic cells which accompanied with the reduction of mRNA expression of anti-apoptosis proteins survivin, Bcl-2 and Bcl-xl, and Timo AIII elevated cell cycle distribution at sub-G1 phase which might result from the down-regulation of cell cycle regulators cyclin-D and upregulation of cyclin-dependent inhibitor p21 in human pancreatic cancer cell AsPC-1 (Kim et al., 2019b).