CASP3 and osteosarcoma: In osteosarcoma and lung cancer, Timo AIII significantly induced cell apoptosis by regulation of caspase 3, caspase 7 and PARP expressions in MG63 human osteosarcoma cells (Jung and Lee, 2019), and induced cell apoptosis and cell cycle arrest at G0/G1 phase in human no-small-cell lung cancer cell A549 (Jung et al., 2016).