In addition, Wang et al. proved that Timo AIIII reduced the expression of X-linked inhibitor of apoptosis protein (XIAP), which is one of the inhibitor of apoptosis proteins (IAP), in both hepatocellular cancer cells in vitro and in vivo, and suppression of XIAP by siRNA reduced the toxic sensitivity of Timo AIII in hepatocellular cancer cells (Wang et al., 2013). The gene discussed is XIAP; the disease is hepatocellular carcinoma.