CASP3 and hepatocellular carcinoma: In the research field of hepatocellular cancer, Wang et al. found that Timo AIII enhanced the apoptosis cell population by activation of poly-ADP ribose polymerase (PARP) and caspase 3, and Z-VAD-FMK which is a cellular apoptosis inhibitor suppressed Timo AIII-induced cytotoxicity in human hepatocellular cancer cell lines including HepG2, MHCC97L, PLC/PRF/5 and Hep3B (Wang et al., 2013).