Similar changes have also been detected in AD, where studies have reported chronic CNS inflammation (increased IL-1β and IL-6), as well as increased immune cell infiltrate in the CNS (Eugenin et al., 2011; Bhat et al., 2012; Atluri et al., 2015; Chen et al., 2017; Dickens et al., 2017; Baker and Petersen, 2018; Madeira et al., 2018). Here, IL6 is linked to Alzheimer disease.