TARDBP and Alzheimer disease: There was no significant difference in neuronal-derived exosomal concentration of TDP-43 between AD patients with and without symptoms of any neuropsychiatric cluster according to the NPI, including psychosis (medians 0.78 ng/ml vs. 1.10 ng/ml), hyperactivity (medians 1.15 ng/ml vs. 1.00 ng/ml), affect (medians 0.91 ng/ml vs. 1.26 ng/ml), apathy/vegetative (medians 1.08 ng/ml vs. 1.04 ng/ml) and motor disturbance (medians 1.06 ng/ml vs. 1.10 ng/ml) (Figures 3A–E).