It has been demonstrated that TDP-43 is secreted via exosomes in neuronal cells contributing to both propagation and clearance of TDP-43 in ALS brains (Iguchi et al., 2016) and can be detected in exosomes from CSF, which originate in the brain (Feneberg et al., 2014). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.