The current National Institute on Aging and Alzheimer’s Association (NIA-AA) research framework posits that the decline in cognitive function of AD is mainly attributable to the interaction of amyloid plaques, neurofibrillary tau deposits and neurodegeneration (Jack et al., 2018) in which TDP-43 is involved but may not be a determinant. The gene discussed is MAPT; the disease is Alzheimer disease.