TARDBP and Alzheimer disease: The burden of TDP-43 accumulation was observed to be correlated with progression of AD, such as volumetric reductions in the hippocampal and entorhinal cortex, decline in memory, naming, general cognition, and global function, particularly during the early phases of neurodegeneration (Josephs et al., 2014a, b, 2015, 2016, 2017; McAleese et al., 2017; Flanagan et al., 2018).