MAPT and Alzheimer disease: Neuronal-derived exosomes (NDEs) have been successfully isolated from plasma, and analyzed for the expression of AD biomarkers, such as Aβ, tau, cellular survival factors, lysosomal proteins, insulin receptor substrate and synaptic proteins in previous studies (Fiandaca et al., 2015; Goetzl et al., 2015a, b, 2016; Kapogiannis et al., 2015; Mustapic et al., 2017).