Recently, it has been observed that there is a correlation between TDP-43 burden and Aβ deposition (Wennberg et al., 2018; Bayram et al., 2019) and increased hippocampal TDP-43 pathology is associated with advanced tau neurofibrillary tangle pathology (Smith et al., 2018) in patients with AD. The gene discussed is MAPT; the disease is Alzheimer disease.