The second-most common neurodegenerative disease among older adults, Parkinson’s disease (PD) manifests as various motor and non-motor symptoms primarily attributable to the excessive accumulation of toxic alpha-synuclein and a series of secondary alterations (de Lau and Breteler, 2006; Suchowersky et al., 2006; Narayanan et al., 2013; Chung et al., 2016; Huang et al., 2016; Sundaram et al., 2019; Li et al., 2020). Here, SNCA is linked to Parkinson disease.