Recent studies have identified a biomarker panel that included blood-based markers that significantly increased alpha-1-Antichymotrypsin, β-amyloid, superoxide dismutase, and homocysteine levels as well as decreased calcium, albumin, dehydroepiandrosterone sulfate, apolipoprotein E, hemoglobin, and BDNF levels in AD (Dekosky et al., 2003; Laske et al., 2011; Doecke et al., 2012; Ng et al., 2019; Pan et al., 2019). This evidence concerns the gene APOE and Alzheimer disease.