Also, Terada et al. (2016) using the second-generation TSPO-specific radioligand [11C]-N, N-diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide ([11C]-DPA713) in early PD patients observed microglial activation all over the cortex. Here, TSPO is linked to Parkinson disease.