IL6 and Alzheimer disease: Several SASP factors, including IL-6, IL-1β, TNF-α, MMP-1, MMP-3, and MMP-10, have also been found to be elevated in the cerebrospinal fluid (CSF) and serum of AD patients (Wood et al., 1993; Blum-Degena et al., 1995; Leake et al., 2000; Horstmann et al., 2010; Gezen-Ak et al., 2013).