Nociceptors express receptors for and were found to be sensitized by interleukin (IL)-1β (Binshtok et al., 2008) or Chemokine (C-C motif) ligand 3 (CCL3) (Zhang et al., 2005) in the context of pain, IL-5 in asthma (Talbot et al., 2015), IL-4 and thymic stromal lymphopoietin (TSLP) in atopic dermatitis (Oetjen et al., 2017), IL-31 during itch (Cevikbas and Steinhoff, 2012), IL-33 after contact with poison ivy (Liu et al., 2016), and IL-23 in the context of psoriasis (Riol-Blanco et al., 2014). The gene discussed is CCL3; the disease is asthma.