More specifically, a mouse model of Dravet syndrome (Scn1a+/−) had previously been associated with a loss of excitability in PV+ and SOM+ cells, which both express Nav1.1 (Yu et al., 2006; Ogiwara et al., 2007; Tai et al., 2014; De Stasi et al., 2016; Favero et al., 2018). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.