VIP+ cells can also contribute to the pathogenesis of Dravet syndrome, a neurodevelopmental disorder associated with a loss of functional variants of the gene SCN1A that encodes for the Nav1.1 channel subunits (Goff and Goldberg, 2019). Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.