NLRP3 and ischemic stroke: Besides, ruscogenin is a crucial steroid sapogenin derived from Ophiopogn japonicus, and ruscogenin could improve neurological dysfunctions of ischemic stroke mice via suppressing expression levels of NLRP3, IL-1β, caspase-1, TXNIP, MAPK, and ROS (Cao et al., 2016).