These results are also observed after the administration of a potent CSF1R inhibitor leading to partial depletion of the microglial population in the 3xTg (Dagher et al., 2015) and 5xFAD models (Spangenberg et al., 2016; Sosna et al., 2018) of AD-like pathology. Here, CSF1R is linked to Alzheimer disease.