SPI1 and acute myeloid leukemia: Newly described pharmacological PU.1 inhibitors have been recently developed (Munde et al., 2014; Stephens et al., 2016) and tested in murine and human acute myeloid leukemia (AML; Xeno) transplantation models, decreasing leukemia progression without affecting normal hematopoietic differentiation (Antony-Debre et al., 2017).