Amyloid deposits from different proteins such as TDP-43, C9ORF72 dipeptide repeats (DPRs), phosphorylated high molecular weight neurofilament protein (pNFH), rho guanine nucleotide exchange factor (RGNEF), and FUS have been detected in ALS MNs (Blokhuis et al., 2013). This evidence concerns the gene ARHGEF28 and amyotrophic lateral sclerosis.