SLC12A5 and myoclonic epilepsy: At the same time, hypomethylation in specific genes was observed in (myoclonic) epilepsy, such as in genes encoding the Na-K-2Cl cotransporter isoform 1 (NKCC1) and the K-Cl cotransporter isoform 2 (KCC2), which affect accumulating and extruding chloride ion (Cl-) flows (Genc et al., 2019).