SP1 and Alzheimer disease: Taking into account that SP1 is a transcription factor promoting P2X7R expression (Garcia-Huerta et al., 2012) and that neuroinflammation causes SP1 upregulation via activation of intracellular kinases cascades (Citron et al., 2008), it is reasonable to think that dysregulation of SP1 may be the factor causing P2X7R upregulation detected in AD.