Later studies supplied additional proofs supporting the involvement of P2X7R in the amyloidogenic APP processing (Delarasse et al., 2011; Diaz-Hernandez et al., 2012), synaptic dysfunction (Lee et al., 2011; Saez-Orellana et al., 2016, 2018; Goncalves et al., 2019), oxidative stress (Parvathenani et al., 2003; Lee et al., 2011; Zhang et al., 2015), and neuroinflammation (Kim et al., 2007; Sanz et al., 2009; Chiozzi et al., 2019; Martin et al., 2019; Martinez-Frailes et al., 2019), associated to AD (Figure 1). This evidence concerns the gene APP and Alzheimer disease.