Elevated p53 increases mutant HTT aggregation and inhibits NF-κB activity and miR-146a expression in mouse and cell models of HD (Ghose et al., 2011), and a reduction in the miR-146a level upregulates TBP in the STHdhQ111 cell lines (Sinha et al., 2010), all of which might contribute to HD. Here, TBP is linked to Huntington disease.