The WWOX gene is an important transcriptional regulator, known to modulate the activity of a number of transcriptional factors and molecular pathways (including Jun, AP2gamma, NFkappaB, and ErbB4) and implicated in tumor suppressor activity, steroid-hormone metabolism regulation and brain development (Aldaz et al., 2014; Iatan et al., 2014). This evidence concerns the gene TFAP2C and neoplasm.