WWOX and developmental and epileptic encephalopathy, 28: Biallelic pathogenic WWOX variants have been implicated in WWOX-related epileptic encephalopathy (WOREE syndrome; MIM 616211), a very rare and severe neurological disorder characterized by absence of language development and acquisition of walking, drug-resistant seizures, ophthalmological involvement and a high likelihood of premature death (Tabarki et al., 2015a, b; Johannsen et al., 2018; Piard et al., 2018).