WWOX (MIM 605131) encodes a WW domain-containing oxidoreductase known to be involved in several cellular and biological processes, including tumor suppression, cell growth and differentiation, regulation of steroid metabolism, induction of apoptosis and central nervous system (CNS) development (Bednarek et al., 2001; Aldaz et al., 2014; Iatan et al., 2014; Tanna and Aqeilan, 2018). This evidence concerns the gene WWOX and neoplasm.