Proteins including Aβ, tau, α-synuclein, and nuclear transactive response DNA-binding protein 43 (TDP-43) are critically implicated in the pathogenesis of several different neurodegenerative diseases, and have been utilized as neurobiological markers to monitor neuronal damage following TBI, moreover, different marker binding fingerprints may function as predictors for a particular late-onset neurodegenerative disease (Williams et al., 2018). This evidence concerns the gene MAPT and neurodegenerative disease.