TARDBP and Huntington disease: For instance, studies have revealed that cell-cell signaling within the NVU is crucial in the pathogenesis of HD and that TDP-43 pathology may feature in HD (Gu et al., 2005; Shin et al., 2005; Gu et al., 2007; Faideau et al., 2010; Johnson et al., 2011; Jansen et al., 2017).