APOE and neurodegenerative disease: Moreover, despite universal occurred NVU dysfunction, only a subgroup of TBI victims develop late-onset neurodegenerative diseases, indicating other factors should be taken into consideration, such as genetic susceptibility (e.g., APOE genotyping) (Baugh et al., 2012; Goldstein et al., 2012; Shively et al., 2017; LoBue et al., 2019).