Analysis of the muscle cell line C2C12 expressing mTBP indicates that MYOD has decreased occupancy on promoters of target muscle genes such as Mhc4 and Mck. Importantly, overexpression of MYOD alleviates muscle degeneration in TBP-105Q knockin mice, further confirming its central role in SCA17 muscle pathology (Huang S. et al., 2015). Here, TBP is linked to spinocerebellar ataxia type 17.