Other converging disease pathways are implicated in the activation of immune response genes including interferon response and chronic neuroinflammation, and are prominent in SCA1, SCA3, SCA6 SCA7, and SCA17 as well as HD (Merienne et al., 2007; Chort et al., 2013; Aikawa et al., 2015; Yang et al., 2017; Driessen et al., 2018; Palpagama et al., 2019; Liu et al., 2020; Niewiadomska-Cimicka et al., 2020). The gene discussed is ATXN1; the disease is Huntington disease.