SNCA and Parkinson disease: A LE/MVB-related mechanism for the biogenesis of LBs is consistent with recent ultrastructural studies revealing that LBs from sporadic PD patients are surrounded by a membrane, and comprised of intraluminal α-synuclein along with abundant intraluminal vesicular structures, membrane fragments and dysmorphic organelles (Shahmoradian et al., 2019), a topology very reminiscent of a LE/MVB with its surrounding membrane and intraluminal vesicles.