In addition, in a Drosophila model, loss of Rab7 in neurons causes adult-onset degeneration beginning with a loss of synaptic function (Cherry et al., 2013), warranting further in vivo studies to address the role of Rab7 in neurodegeneration and specifically in LRRK2-related PD pathogenesis. The gene discussed is LRRK2; the disease is Parkinson disease.