In an another study, epidermal growth factor receptors (EGFRs)-targeted therapy explored for treatment of glioma where angiopep-2 (A2)-modified cationic lipid-poly (lactic-co-glycolic acid) (PLGA) nanoparticle (A2-N) loaded Gefitinib (Ge), an EGFR tyrosine kinase inhibitor (TKI) and Golgi phosphoprotein 3 (GOLPH3)-siRNA were prepared. This evidence concerns the gene GOLPH3 and central nervous system cancer.