Chronic PDE10 inhibitor administration has also been reported to attenuate cortical and striatal neurodegeneration, improve motor behavior, increase life-span, and elevate activated CREB in MSNs in the quinolinic acid and R6/2 models of HD (Giampa et al., 2009a, Giampa et al., 2010). The gene discussed is CREB1; the disease is Huntington disease.