Elevations in cyclic nucleotide levels and CREB phosphorylation induced following PDE10A inhibition were also found to augment corticostriatal transmission, rescue hippocampal LTP, and reverse basal ganglia dysfunction in the R6/2 and Q175 HD mouse models via cAMP and cGMP-dependent mechanisms (Beaumont et al., 2016). Here, CREB1 is linked to Huntington disease.