PDPN and neoplasm: Besides the PDPN-CLEC-2 axis, several interactions with cell surface molecules have been reported for tumor cell-induced platelet aggregation, including interactions between ADMA10, galectin-3,αV βIII and CD97 on tumor cells and α6β1, gpVI, αIIbβIII and an unidentified target on platelets, respectively [18, 20, 36, 37].