Here, the distribution of the allele and genotype frequencies of 12 important pharmacogenomic markers related to 6-MP and MTX, the principal drugs used in the treatment of ALL, was compared between Amerindian (NAT) populations and five representative populations from the 1,000 Genomes database, using Fisher’s exact test with the standard statistical correction (FDR) being used to avoid misleading correlations. Here, BRD2 is linked to acute lymphoblastic leukemia.