These now include the Wnt receptor Frizzled 8 (FZD8),8 the tumour suppressor phosphatase and tensin homologue (PTEN),9 and the α1 and β1 subunits of soluble guanylyl cycles (GUCY1A3 and GUCY1B3),10 the latter indicating that TMPRSS2:ERG can activate NO-cGMP signalling in PCa. Here, TMPRSS2 is linked to posterior cortical atrophy.