It has been established that ERG drives the oncogenic properties of PCa cells through Wnt/β-catenin activation and in line with this we saw reduced activation of the Wnt receptor LRP6 (p-LRP6) and reduced levels of the downstream executor of the pathway β-catenin, alongside reduced expression of Wnt pathway genes cyclin D1 and c-Myc upon SSO transfection. The gene discussed is ERG; the disease is posterior cortical atrophy.