Furthermore, when we correlated drug AUCs with SAMHD1 expression, nelarabine displayed the most significant direct correlation with SAMHD1 expression across all ALL cell lines, the second most significant direct correlation with SAMHD1 expression in the B-ALL cell lines, and the third most significant direct correlation with SAMHD1 expression in the T-ALL cell lines (Supplementary Data 4). The gene discussed is SAMHD1; the disease is acute lymphoblastic leukemia.