SYK and pancreatic adenocarcinoma: Interestingly, PAK1 was found as a DEG in TCGA data from both LUAD and PAAD patients (Supplementary Figure 13D, 14A,B, 15A,–C), whereas SYK was found as a DEG in CCLE data from lung, pancreas and colon cell lines (Fig. 4B, 10D) as well as in TCGA data from LUAD and PAAD patients (Supplementary Figure 13D, 15A), which collectively revealed that PAK1 and SYK indeed may be critical genes for downstream signaling in the context of Ras independency.