Deletion of CASP4 or GSDMD did not alter bacterial invasion, but abrogated Salmonella-induced IFNγ-dependent cell death (Fig. 1c and Supplementary Fig. 1h–k), confirming that Salmonella infection of HeLa cells activates the non-canonical inflammasome in an IFNγ-dependent manner. The gene discussed is GSDMD; the disease is Salmonella Infections.