Of note, the earliest infection among macaques administered 10–1074 occurred in animal 10–139 following five SHIVSF162P3 challenges and corresponded with an abrupt decline in the neutralization activity of 10–1074 in plasma between 3 and 5 weeks post injection, due to the development of an antidrug antibody (ADA) response (Fig. 1b, Supplementary Fig. 1)41,42. The gene discussed is ADA; the disease is infection.