Therefore, considering the results of previous studies, we propose the following inflammatory cascade as a possible mechanism behind CRD-related enhanced tumourigenesis and metastatic spread (Fig. 7): CRD increases the expression of Cxcl5 in tumours, leading to enhanced infiltration of CXCR2+ myeloid cells, e.g. MDSCs. The gene discussed is CXCR2; the disease is neoplasm.