CXCR4 and cancer: Collectively, these data support the existence of CRD-driven alterations in the cytokine–chemokine network that promote cancer-cell dissemination and the immune-suppressive tumour phenotype: potentially a more prominent CXCL12-CXCR4 axis favouring cancer-cell dissemination and specifically, an enhanced role for the CXCL5-CXCR2 axis that enriches immune-suppressive cell types in the tumour microenvironment.